Search results for "Discriminant model"

showing 4 items of 4 documents

STATISTICAL METHODS FOR THE DISCRIMINATION OF FOUR FORMS OF DIPLEGIA

FUNCTIONAL PRINCIPAL COMPONENT ANALYSISLINEAR DISCRIMINANT MODELDIPLEGIA
researchProduct

Fusion of the

2015

Chronic obstructive pulmonary disease, COPD, affects the condition of the entire human organism and causes multiple comorbidities. Pathological lung changes lead to quantitative changes in the composition of the metabolites in different body fluids. The obstructive sleep apnea syndrome, OSAS, occurs in conjunction with chronic obstructive pulmonary disease in about 10–20 % of individuals who have COPD. Both conditions share the same comorbidities and this makes differentiating them difficult. The aim of this study was to investigate whether it is possible to diagnose a patient with either COPD or the OSA syndrome using a set of selected metabolites and to determine whether the metabolites t…

NMR spectroscopyOriginal ArticleChronic obstructive pulmonary disease (COPD)ChemometricsObstructive sleep apnea syndrome (OSAS)Discriminant modelsrespiratory tract diseasesMetabolomics : Official journal of the Metabolomic Society
researchProduct

New hypoglycaemic agents selected by molecular topology.

2003

Abstract New compounds showing hypoglycaemic activity have been designed through a computer aided method based on quantitative structure–activity relationship (QSAR) and molecular connectivity. After calculation of topological indices for a set of 89 compounds including active and inactive with regards to hypoglycaemic action, linear discriminant analysis was performed so that a useful model to predict such an activity was achieved. Later on, the discriminant model was applied on a huge database so that fourteen compounds were selected as potential new hypoglycaemics. From them, just five were finally selected for experimental test on expected hypoglycaemic activity. Among the selected comp…

Quantitative structure–activity relationshipMolecular StructureDiscriminant modelPharmaceutical ScienceQuantitative Structure-Activity RelationshipPharmacologyLinear discriminant analysischemistry.chemical_compoundTolbutamidechemistryArabitolDrug DesignmedicinePotencyHypoglycemic AgentsMolecular topologymedicine.drugInternational journal of pharmaceutics
researchProduct

Fusion of the 1H NMR data of serum, urine and exhaled breath condensate in order to discriminate chronic obstructive pulmonary disease and obstructiv…

2015

Chronic obstructive pulmonary disease, COPD, affects the condition of the entire human organism and causes multiple comorbidities. Pathological lung changes lead to quantitative changes in the composition of the metabolites in different body fluids. The obstructive sleep apnea syndrome, OSAS, occurs in conjunction with chronic obstructive pulmonary disease in about 10–20 % of individuals who have COPD. Both conditions share the same comorbidities and this makes differentiating them difficult. The aim of this study was to investigate whether it is possible to diagnose a patient with either COPD or the OSA syndrome using a set of selected metabolites and to determine whether the metabolites t…

medicine.medical_specialtyPathology(COPD)Endocrinology Diabetes and MetabolismMetaboliteClinical BiochemistryChronic obstructive pulmonary disease (COPD)Urinediscriminant modelsBiochemistryGastroenterologychronic obstructive pulmonary diseasechemistry.chemical_compoundNMR spectroscopyInternal medicinePartial least squares regressionMedicineExhaled breath condensatePathologicalCOPDLungbusiness.industrymedicine.diseasechemometricsrespiratory tract diseasesObstructive sleep apneamedicine.anatomical_structurechemistrybusinessobstructive sleep apnea syndrome (OSAS)Metabolomics
researchProduct